16th International Symposium of Trace Elements in man and Animals
Michael Aschner, PhD, Prof.

Michael Aschner, PhD, Prof.

Report: Manganese neurotoxicity

Affiliation and position:

Albert Einstein College of Medicine, Harold and Muriel Block Chair in Molecular Pharmacology; Professor of Molecular Pharmacology, Neuroscience, Pediatrics; Investigator, Rose F. Kennedy Intellectual and Developmental Disabilities Research Center; Member, Nathan Shock Center of Excellence in the Basic Biology of Aging.

Research interests:

  1. Metal Neurotoxicity
  2. Neurodegenerative diseases
  3. Astrocyte Physiology
  4. Alternative Models

Key publications for the last 5 years:

  1. Martinez-Finley E, Chakraborty S, Slaughter JC, Aschner M. Early-Life Exposure to Methylmercury in Wildtype and pdr-1/parkin Knockout C. elegans. Neurochem Res 2013; 38:1543-1552.
  2. Bornhorst J, Chakraborty S, Meyer S, Lohren H, Brinkhaus S, Knight AL, Caldwell KA, Caldwell GA, Karst U, Schwerdtle T, Bowman AB, Aschner M. The effects of pdr1, djr1.1 and pink1 loss in manganese-induced toxicity and the role of α-synuclein in C. elegans. Metallomics 2014; 6:476-490.
  3. Exil V, Ping P, Yu Y, Chakraborty S, Caito SW, Wells SK, Aschner M. Activation of MAPK and FoxO deactivation with manganese exposure in rat neonatal primary astrocytes. PLos One 2014; 9(5):e94753. doi: 10.1371/journal.pone.0094753.
  4. Leyva-Illades D, Chen P, Zogzas CE, Swaim CD, Bowman AB, Mukhopadhyay S, Aschner M. Mutations in SLC30A10 block its intracellular trafficking and manganese efflux activity to cause a hereditary parkinsonian disorder. J Neurosci 2014; 34:14079-14095.
  5. Chakraborty S, Chen P, Bornhorst J, Schwerdtle T, Schumacher T, Kleuser B, Bowman AB, Aschner M. Loss of pdr-1/parkin influences Mn homeostasis through altered ferroportin expression in C. elegans. Metallomics 2015; 7:847-856.

Journal referee:

  1. Toxicological Sciences
  2. Toxicology and Applied Pharmacology
  3. Neurochemistry Research
  4. F1000
  5. American Journal of Neurochemistry

Scientific societies:

  1. Society of Toxicology
  2. American Society of Neurochemistry