16th International Symposium of Trace Elements in man and Animals
Prof. Dr. rer. nat. Dr. habil. Bernhard MICHALKE

Bernhard Michalke, PhD, Dr. rer. nat., Dr. habil., Prof.

Report: Speciation in Trace Elements Analysis: Combination with Metabolomics and Application to Neurodegenerative Disorders

Affiliations and positions:

  1. 2012 – now
    Position: Deputy Director and Group Leader
    Helmholtz Center Munich – German Research Center for Environmental health
    Research Unit: Analytical BioGeoChemistry
    Neuherberg/Munich, Germany
  2. 2005 – 2012
    Position: Group Leader
    Helmholtz Center Munich – German Research Center for Environmental health
    Institute of Ecological Chemistry
    Neuherberg/Munich, Germany
  3. 1988 – 2005
    Position: Deputy Group Leader and Coordinator of Service Analytics
    GSF Forschungszentrum für Umwelt und Gesundheit GmbH (today renamed into Helmholtz Center Munich)
    Institute of Ecological Chemistry
    Neuherberg/Munich, Germany

Research interests:

  1. Element speciation with respect to neurodegenerative disorders (now main research interest)
  2. Set up and developments for Element Speciation Analysis
  3. Investigations on element speciation in bio-medical and environmental samples
  4. Development of hyphenated techniques and quality control strategies in element speciation analysis

Key publications for the last 5 years:

  1. Bernhard Michalke
    Review about the Manganese Speciation Project related to Neurodegeneration: An Analytical Chemistry Approach to Increase the Knowledge about Manganese related Parkinsonian Symptoms
    Journal of Trace Elements in Medicine and Biology, (2016) DOI:10.1016/j.jtemb.2016.03.002
    Open access, online since March 7th, 2016
  2. Katharina Neth, Marianna Lucio, Alesia Walker, Julia Zorn, Philippe Schmitt-Kopplin, Bernhard Michalke
    Changes in Brain Metallome/Metabolome Pattern due to a Single i.v. Injection of Manganese in Rats
    PLOS ONE | September 18, (2015) Volume: 10 Issue: 9 Pages: e0138270 Open access . Published: 2015
    DOI:10.1371/journal.pone.0138270
  3. Katharina Neth, Marianna Lucio, Alesia Walker, Basem Kanawati, Julia Zorn, Phillippe-Schmitt-Kopplin and Bernhard Michalke
    Diverse Serum Manganese Species affect Brain Metabolites depending on Exposure Conditions
    Chem.Res. Toxicol, (2015) Volume: 28 Issue: 7 Pages: 1434-1442 Published: JUL 2015
  4. B. Michalke, L. Aslanoglou, M. Ochsenkühn-Petropoulou, B. Bergstrom, A. Berthele, M. Vinceti, Marianna Lucio, G. Liden
    A Manganese carrier switch in serum from transferrin to citrate at slightly elevated Mn concentration could be used for Manganese biomonitoring
    Journal of Trace Elements in Medicine and Biology 32 (2015) 145–154
  5. Katharina Fernsebner, Julia Zorn, Basem Kanawati, Alesia Walker and Bernhard Michalke
    Manganese leads to an increase in markers of oxidative stress as well as to a shift in the ratio of Fe(II)/(III) in rat brain tissue
    Metallomics (2014), Volume: 6 Issue: 4 Pages: 921-931
    DOI: 10.1039/c4mt00022f
  6. Marco Vinceti, Nikolay Solovyev, Jessica Mandrioli, Catherine M. Crespi , Francesca Bonvicini, Elisa Arcolin, Eleni Georgoulopoulou, Bernhard Michalke
    Cerebrospinal fluid of newly diagnosed amyotrophic lateral sclerosis patients exhibits abnormal levels of selenium species including elevated selenite
    NeuroToxicology 38 (2013) 25–32

Journal referee:

  1. Journal of Trace Elements in Medicine and Biology
  2. Journal of Analytical Atomic Specetrometry
  3. Metallomics
  4. Analytica Chimica Acta
  5. Analytical and Bioanalytical Chemistry

Scientific societies:

  1. Gesellschaft für Mineralstoffe und Spurenelemente e.V.
  2. Federation of European Societies of Trace Elements and Minerals
  3. Royal Society of Chemistry